Architectural Design & Planning Problems typically involve challenging requirements, constraints, and competing goals pertaining to social, economic, and environmental values as well as human factors, spatial ergonomics, and comfort that bring about both physical and human complexities. Furthermore, balancing the suitability of solutions with respect to the expected operational functionality of spatial configurations & forms and their adaptability towards future requirements are often challenging. Research and Development in “Generative Systems & Sciences'' revolves around mathematically or computationally modelling the human-physical complexity of design & spatial decision-making as well as promoting the idea of scientific design as open and modular participatory processes of scientific discovery and innovation. The general quest of this line of inquiry is to develop interactive/gamified spatial, multi-criteria, and multi-actor Generative Design Decision-Support Systems to contribute to the open-source development of equitable, circular, and sustainable buildings and cities. Generative Sciences, as interdisciplinary approaches based on Network Models, are suited for simulating the interactions of intricate webs of inter-related spaces, criteria, actors, and values; and as such, provide a basis for understanding and controlling the formation of patterns and emergence of collective decisions in Digital Twins. Generative Systems, as simulation systems (possibly human-machine hybrids), can provide mechanisms for logical transitions from design requirements, considerations, and values to suitable and adaptable design alternatives.